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Penn Researchers Find New Risk Factor for Second-Most-Common Form Of Early-Onset Dementia

Examining brain tissue from over 500 individuals in 11 countries, researchers from the University of Pennsylvania School of Medicine and the Children’s Hospital of Philadelphia, and colleagues found a new risk factor for the second-most-common cause of early-onset dementia after Alzheimer’s disease. “Using a genome-wide scan for genetic variation in post-mortem brain tissue, we were […]

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Elk-1 Plague

Penn Study Finds That Three Brain Diseases Are Linked By A Toxic Form Of The Same Neural Protein

For the first time, researchers from the University of Pennsylvania School of Medicine have found that three different degenerative brain disorders are linked by a toxic form of the same protein. The protein, called Elk-1, was found in clumps of misshaped proteins that are the hallmarks of Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease. (continue […]

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Human_Genome

Research Identifies Gene With Likely Role In Premenstrual Disorder

Scientists have identified a gene they say is a strong candidate for involvement in premenstrual dysphoric disorder (PMDD) and other maladies associated with the natural flux in hormones during the menstrual cycle. In a paper published Monday in the Proceedings of the National Academy of Sciences, Rockefeller University researchers detail experiments in mice showing that […]

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Protein produced by PBRM1 gene; Source: UCSC Genome Browser

Same Genes Suspected In Both Depression And Bipolar Illness

Researchers, for the first time, have pinpointed a genetic hotspot that confers risk for both bipolar disorder and depression. People with either of these mood disorders were significantly more likely to have risk versions of genes at this site than healthy controls. One of the genes, which codes for part of a cell’s machinery that […]

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a girl with a headache

Migraine And Depression May Share Genetic Components

New research shows that migraine and depression may share a strong genetic component. The research is published in the January 13, 2010, online issue of Neurology, the medical journal of the American Academy of Neurology. “Understanding the genetic factors that contribute to these disabling disorders could one day lead to better strategies to manage the […]

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epigenetic_mechanisms

Silenced Gene For Social Behavior Found In Autism That Could Serve As A Biomarker

Autism research continues to emerge at a steady pace. “A new, integrated interpretation of Autism Spectrum Disorders (ASD)” was recently reported. Now, researchers have found a potential biomarker for Autism as, for the first time, inherited disruption of gene expression in a brain system for social behavior has been implicated in autism. National Institute of […]

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