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DNA

Trauma-Induced Changes To Genes May Lead To PTSD

A study by researchers at Columbia University’s Mailman School of Public Health suggests that traumatic experiences “biologically embed” themselves in select genes, altering their functions and leading to the development of post-traumatic stress disorder (PTSD). “Our findings suggest a new biological model of PTSD in which alteration of genes, induced by a traumatic event, changes […]

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Virus

The Impact Of Infections And Stress On Children With Tourette Syndrome And OCD

PANDAS is an abbreviation for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections. This diagnosis was created when clinicians observed that following streptococcal infections, which include strep throat, scarlet fever, and impetigo, children developed tics and symptoms of obsessive-compulsive disorder (OCD). (read the full story)

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Infant

Mother’s Flu During Pregnancy May Increase Her Baby’s Risk Of Schizophrenia

Roulette Smith, Ph.D. has long advocated the role of viruses in many different disorders (see: A Novel and Potentially Groundbreaking Viral Theory of Autism and Schizophrenia), including schizophrenia and Autism. Now researchers at University of Wisconsin-Madison in collaboration with the University of North Carolina at Chapel Hill report that Rhesus monkey babies born to mothers […]

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(click to enlarge) Canine retina two years post injection.  Retinal photograph taken more than two years after subretinal injection of AAV2-hRPE65v2 in the second eye of a dog model of Leber's congenital amaurosis due to RPE65 mutations. The AAV-exposed portion of the retina, with the overlying inner retinal blood vessels, appears yellow due to reflective changes in the underlying tapetum.

Second Dose Of Gene Therapy For Inherited Blindness Proves Safe In Animal Studies

Gene therapy for a severe inherited blindness, which produced dramatic improvements last year in 12 children and young adults who received the treatment in a clinical trial, has cleared another hurdle. The same research team that conducted the human trial now reports that a study in animals has shown that a second injection of genes […]

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Bacteria (Streptococcus pneumoniae, red) under attack by a neutrophil (blue). Credit: Jeffrey Weiser, PhD, University of Pennsylvania School of Medicine

“Good” Bacteria Keep Immune System Primed To Fight Future Infections

Scientists have long pondered the seeming contradiction that taking broad-spectrum antibiotics over a long period of time can lead to severe secondary bacterial infections. Now researchers from the University of Pennsylvania School of Medicine may have figured out why. The investigators show that “good” bacteria in the gut keep the immune system primed to more […]

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Protecting the brain. New experiments show a special population of the immune system’s sentinels, dendritic cells (green), at work in the brain. Brain dendritic cells gather around the border of stroke-damaged brain tissue and also stimulate T cells (red) to fight off infections. (image credit: Rockefeller)

First Evidence That Native Dendritic Cells Of The Brain Can Muster An Immune Response

The human brain is a delicate organ, robustly defended. A thick skull shields it from any direct exposure to the outside world, and the blood-brain barrier keeps out any foreign substances that are circulating within. New research shows that the brain may have its own specialized immune defenses, too. In 2008, researchers at Rockefeller University […]

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Virus

Further Doubt Cast On A Virus Link To Chronic Fatigue

Researchers investigating UK samples have found no association between the controversial xenotropic murine leukaemia virus-related virus (XMRV) and chronic fatigue syndrome (CFS). Their study, published in BioMed Central’s open access journal Retrovirology, calls into question a potential link described late last year by an American research team. Check the end of this review for a […]

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