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Fluorescent labeling of CalDAG-GEFI (red) and Htt (green) shows abundant expression of CalDAG-GEFI in the striatum of control mice (left panel) but severely down-regulated expression in striatal neurons of the Huntington's disease model mice (right panel). Aggregated Htt, a hallmark of Huntington's disease, is apparent in the neurons of mutant mice (green particles, right panel). Image courtesy Jill Crittenden/MIT

MIT Neuroscientists Unveil Molecular Pathway Involved With Huntington’s Disease

MIT researchers have discovered new molecular changes in the brains of individuals with Huntington’s disease, a genetic disorder that leads to neuronal loss accompanied by unwanted movements, psychiatric symptoms, and eventual death. By studying brains of human patients, as well as mouse and rat models, they have uncovered a protective response that may eventually lead […]

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Elk-1 Plague

Penn Study Finds That Three Brain Diseases Are Linked By A Toxic Form Of The Same Neural Protein

For the first time, researchers from the University of Pennsylvania School of Medicine have found that three different degenerative brain disorders are linked by a toxic form of the same protein. The protein, called Elk-1, was found in clumps of misshaped proteins that are the hallmarks of Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease. (continue […]

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