“We found that current major depression increased the risk of crack use, but depression in the past year that had gotten better did not,” said Jennifer Johnson, assistant professor (research) of psychiatry and human behavior in the Warren Alpert Medical School of Brown University and lead author of the study. “This suggests that if the depression remits, the risk of crack use goes down. Screening for depression and effective depression treatment may be important components of drug court services.”
Addiction and depression are closely associated, said Johnson, who is also affiliated with Brown’s Center for Alcohol and Addiction Studies. It isn’t always clear how the two affect each other, especially at an urgent moment such as entry into the court system. Johnson set out to untangle the two by analyzing data gathered by researchers at Washington University in St. Louis as part of an HIV prevention study.
Among the 261 women in the study, 16 percent had a current major depressive episode and 40 percent had experienced a major depressive episode in their lifetime. Among the women currently depressed, 46 percent used crack during the next four months. Among women who weren’t currently depressed, only 25 percent used crack in the next four months.
At the beginning of the study, the analysis statistically adjusted for whether women were using crack, which is highly addictive, and took the timing of the women’s depression into account, said Johnson, who is also affiliated with the Center for Prisoner Health and Human Rights, a collaboration of Brown University and The Miriam Hospital.
Women who had been depressed at some time in the past, even in the last year, did not have an increased risk of crack use compared to women who had never been depressed, Johnson found. Women who were currently depressed, however, were significantly more likely to use crack than women who were never depressed. Furthermore, currently depressed women had nearly four times the odds of using crack during follow-up compared to women who had been depressed at some point in their past. The odds were nearly six times greater compared to women who were depressed within the last year, but not currently.
“It doesn’t matter if they’ve been depressed in the past,” she said, “only how they’re doing right now.”
The data hint that depression may have contributed to crack use in this population, Johnson said.
“It is well known that crack use can cause depression and depression can contribute to crack use,” Johnson said. “However, in this study baseline depression [at the beginning of the study] was not associated with baseline crack use, but was associated with future crack use, suggesting that depression may have led to crack use and not vice versa.”
If women in drug court can be successfully screened and treated for depression, Johnson said, the resulting reduction in crack use predicted by the analysis might benefit not only the women but also the community.
“The public ends up paying the cost of drug court and incarceration,” she said. “Depression treatment isn’t that expensive.”
In addition to Johnson, the paper’s other authors are Linda B. Cottler, Catina O’Leary, Catherine W. Striley, Arbi Ben Abdallah, and Susan Bradford, all of Washington University. Cottler’s grant from the National Institute of Nursing Research funded the original HIV-prevention study for which the data was acquired. Johnson’s analysis of addiction and depression was supported by a grant from the National Institute on Drug Abuse.
Material adapted from Brown University.