There's An Elephant In The Room - It's Called "Essential Hypertension"
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Most bacterial infections can be treated with antibiotics such as penicillin, discovered decades ago. However, such drugs are useless against viral infections, including influenza, the common cold, and deadly hemorrhagic fevers such as Ebola. Now, in a development that could transform how viral infections are treated, a team of researchers at MIT’s Lincoln Laboratory has designed a drug that can identify cells that have been infected by any type of virus, then kill those cells to terminate the infection.
The drug Incivek, when given in combination with two other medications, can dramatically increase the chances of people chronically infected with untreated genotype 1 hepatitis C virus achieving a viral cure. That is the finding of a study published in the June 23rd issue of the New England Journal of Medicine.
Laboratories at the University of New Mexico (UNM), Brown University, and House Ear Institute (HEI) have developed a new technique to observe herpes simplex virus type 1 (HSV1) infections growing inside cells. HSV1, the cause of the common cold sore, persists in a latent form inside nerve cells. Re-activation and growth of HSV1 infections contribute to cognitive decline associated with Alzheimer’s disease. Details are published in the March 31 issue of PLoS ONE journal from the Public Library of Science. Check the end of this report for a link to download this open access study.
One of the most difficult aspects of working at the nanoscale is actually seeing the object being worked on. Biological structures like viruses, which are smaller than the wavelength of light, are invisible to standard optical microscopes and difficult to capture in their native form with other imaging techniques. A multidisciplinary research group at UCLA has now teamed up to not only visualize a virus but to use the results to adapt the virus so that it can deliver medication instead of disease.
Following up a pioneering 2007 proof-of-concept study, a University of Utah biochemist and colleagues have developed a promising new anti-HIV drug candidate, PIE12-trimer, that prevents HIV from attacking human cells. Michael S. Kay, M.D., Ph.D., associate professor of biochemistry in the University of Utah School of Medicine and senior author of the study published Wednesday, Aug. 18, 2010, online by the Journal of Virology, is raising funds to begin animal safety studies, followed by human clinical trials in two to three years.
Imagine an exceedingly complex circuit board. Wires often split – seemingly at random – and connect in strange and unexpected ways. This is how Princeton University researchers developing a new method for studying brain connectivity see the brain. Included in this report is a link to the original press release that has several cool videos [...]
Researchers investigated immune function and health outcomes in women with depression, as compared with a non-depressed control group. Depression is a biological, psychological, and social illness that affects roughly 15 million American adults in any given year. Depression costs billions of dollars in lost time, productivity, personnel replacement, medical care and, tragically, loss of life. [...]
Gene Transfer Agents has made great advances in the development of novel non-viral carriers able to introduce genetic material into the target cells. These new agents, derivatives of cationic amphiphilic 1,4-dihydropyridine (1,4-DHP), avoid the problems of the recipient’s immune system reacting against a viral carrier. The project partners have developed methods to produce them in [...]
Scientists have uncovered the flu’s secret formula for effectively evolving within and between host species: balance. The key lies with the flu’s unique replication process, which has evolved to produce enough mutations for the virus to spread and adapt to its host environment, but not so many that unwanted genomic mutations lead to the flu’s [...]
A study by researchers at Columbia University’s Mailman School of Public Health suggests that traumatic experiences “biologically embed” themselves in select genes, altering their functions and leading to the development of post-traumatic stress disorder (PTSD). “Our findings suggest a new biological model of PTSD in which alteration of genes, induced by a traumatic event, changes [...]
