In Alzheimer’s disease, the problem is amyloid-β, a protein that accumulates in the brain and causes nerve cells to weaken and die. Drugs designed to eliminate plaques made of amyloid-β have a fatal problem: they need to enter the brain and remove the plaques without attacking healthy brain cells. A new breakthrough from the laboratory of Nobel Prize winner Paul Greengard, however, suggests that treatments ...

Insomnia and other sleep disorders are very common, yet are not generally well understood by doctors and other health care professionals. Now the British Association for Psychopharmacology (BAP) has released up-to-the-minute guidelines in the Journal of Psychopharmacology, published by SAGE, to guide psychiatrists and physicians caring for those with sleep problems. ...

Clinical trials using patients’ own immune cells to target tumors have yielded promising results. However, this approach usually works only if the patients also receive large doses of drugs designed to help immune cells multiply rapidly, and those drugs have life-threatening side effects. Now a team of MIT engineers has devised a way to deliver the necessary drugs by smuggling them on the backs of the cells ...

Depression is actually defined by specific clinical symptoms such as sadness, difficulty to experience pleasure, and sleep problems that are present for at least two weeks with impairment of psychosocial functioning. These symptoms guide the physician to make a diagnosis and to select antidepressant treatment such as drugs or psychotherapy. ...

Adults with attention-deficit/hyperactivity disorder (ADHD) who received medication and individual sessions of cognitive behavioral therapy (CBT) showed greater improvement in symptoms through 12 months compared to patients who did not receive CBT, according to a study in the August 25 issue of JAMA. ...

Following up a pioneering 2007 proof-of-concept study, a University of Utah biochemist and colleagues have developed a promising new anti-HIV drug candidate, PIE12-trimer, that prevents HIV from attacking human cells. Michael S. Kay, M.D., Ph.D., associate professor of biochemistry in the University of Utah School of Medicine and senior author of the study published Wednesday, Aug. 18, 2010, online by the J ...

Yale researchers have discovered how a novel anti-depressant can take effect in hours, rather than the weeks or months usually required for most drugs currently on the market. The findings, described in the August 20 issue of the journal Science, should speed development of a safe and easy-to-administer form of the anti-depressant ketamine, which has already proven remarkably effective in treating severely ...

The pharmaceutical industry is a "market for lemons," a market in which the seller knows much more than the buyer about the product and can profit from selling products less effective and less safe than consumers are led to believe, according to an analysis by sociologist Donald Light that will be presented at the 105th Annual Meeting of the American Sociological Association. Light is a professor of compara ...

Nearly 1 million children in the United States are potentially misdiagnosed with attention deficit hyperactivity disorder simply because they are the youngest – and most immature – in their kindergarten class, according to new research by a Michigan State University economist. The study will appear in a forthcoming issue of the Journal of Health Economics. ...

A new discovery about selective serotonin reuptake inhibitors (SSRIs) suggests that these drugs, which are used to treat mental health disorders like depression and anxiety, have multiple effects on our cells. In a research report published in the August 2010 issue of Genetics, researchers used yeast cells to identify secondary drug targets or pathways affected by SSRIs. Such secondary pathways could help e ...