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Asian women who consumed an average of 200 milligrams or more of caffeine a day — the equivalent of roughly two cups of coffee — had elevated estrogen levels when compared to women who consumed less, according to a study of reproductive age women by researchers at the National Institutes of Health and other institutions. However, white women who consumed 200 milligrams or more of caffeine a day had slightly lower estrogen levels than women who consumed less. Black women who consumed 200 milligrams or more of caffeine a day were found to have elevated estrogen levels, but this result was not statistically significant.

The risk of depression appears to decrease for women with increasing consumption of caffeinated coffee, according to a report in the September 26 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. The research was carried out by Michel Lucas, Ph.D., R.D., from the Harvard School of Public Health, Boston, and colleagues.

A yet unidentified component of coffee interacts with the beverage’s caffeine, which could be a surprising reason why daily coffee intake protects against Alzheimer’s disease. A new Alzheimer’s disease mouse study by researchers at the University of South Florida found that this interaction boosts blood levels of a critical growth factor that seems to fight off the Alzheimer’s disease process.

From high-school students to surgeons, anyone who has pulled an all-nighter knows there is a price to be paid the next day: trouble focusing, a fuzzy memory, and other cognitive impairments. Now, researchers at Penn have found the part of the brain and the neurochemical basis for sleep deprivation’s effects on memory. Their research was published in The Journal of Neuroscience.

Christina Calamaro considers adolescence as more than just a transitional stage between childhood and adulthood. She sees it as an opportunity for positive change. “Adolescence is the last frontier before adulthood, a time when we can look at people’s lives and make real dedicated change,” says Calamaro, PhD, CRNP, assistant professor and director of the School’s Primary Care Pediatric Nurse Practitioner master’s specialty.

Among the many differences between girls and boys, effects from caffeine, including physiological, behavioral, and subjective can be added to the list. Results of a double-blind, placebo-controlled, dose-response study of the response of youth to caffeine found that, in general, boys get a greater rush and more energy from caffeine than girls.

Highly-caffeinated energy drinks – even those containing no alcohol – may pose a significant threat to individuals and public health, say researchers at the University of Maryland School of Public Health and Wake Forest University School of Medicine. The publisher made the original accompanying commentary available for free. Check the end of this report for a download link.

Coffee, that morning elixir, may give us an early jump-start to the day, but numerous studies have shown that it also may be protective against type 2 diabetes. Yet no one has really understood why. Now, researchers at UCLA have discovered a possible molecular mechanism behind coffee’s protective effect. A protein called sex hormone–binding globulin (SHBG) regulates the biological activity of the body’s sex hormones, testosterone and estrogen, which have long been thought to play a role in the development of type 2 diabetes. And coffee consumption, it turns out, increases plasma levels of SHBG.

Marketing efforts that encourage mixing caffeinated “energy” drinks with alcohol often try to sway young people to believe that caffeine will offset the sedating effects of alcohol and increase alertness and stamina. But a new study led by researchers from the Boston University School of Public Health [BUSPH] and the Center for Alcohol and Addiction Studies at Brown University has found that the addition of caffeine to alcohol – mixing Red Bull with vodka, for example – has no effect on enhancing performance on a driving test or improving sustained attention or reaction times. A video interview with lead researcher Jonathan Howland is included in this report.

Caffeine consumption in children is often blamed for sleep problems and bedwetting. Information on childhood caffeine consumption is limited, and many parents may not know the amount or effects of their child’s caffeine consumption. In a study published in The Journal of Pediatrics, researchers found that 75% of children surveyed consumed caffeine on a daily basis, and the more caffeine the children consumed, the less they slept.