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The antipsychotic medication risperidone is more effective for initial treatment of mania in children diagnosed with bipolar disorder compared to other mood stabilizing medications, but it carries the potential for serious metabolic side effects, according to an NIMH-funded study published online ahead of print January 2, 2012, in the Archives of General Psychiatry.

Acetaminophen is one of the most commonly used pain and fever relievers for infants and children and is safe and effective when used as directed. However, with recent dosing changes to liquid acetaminophen products for infants, the FDA last week issued a press release urging parents to know the concentration and read the label as the new, less concentrated form of the popular pain reliever arrives on store shelves. Included in this report is a video discussion of these recommendations by Dr. Jim Sears.

More than 15 percent of Norwegian teenagers ages 15 to 16 reported “mental distress,” or symptoms of depression and anxiety, with significantly more girls reporting distress than boys, according to a new study in the Journal of Adolescent Health. Girls with mental distress were also more likely than their male counterparts to be prescribed psychotropic drugs — those that alter chemical levels in the brain, affecting behavior and mood.

Although there have been cardiovascular safety concerns about attention-deficit/hyperactivity disorder (ADHD) medications because of their ability to increase heart rate and blood pressure levels, an analysis that included more than 150,000 ADHD users found no evidence of an increased risk of heart attack, stroke, or sudden cardiac death associated with current use compared with non-use or rare-use among young and middle-aged adults, according to a study appearing in JAMA. The study is being released early online because of its public health importance. Included in this report is a video summary of the study results.

Investigators in a population-based study in Denmark reporting today at the American Epilepsy Society’s 65th annual meeting have found there is an increased risk of autism spectrum disorder and childhood autism in children born of mothers who are exposed to the anticonvulsant valproate during pregnancy. The Lead investigator was Dr. Jakob Christensen of Aarhus University [...]

Patients with major depression who fail to see improvement after taking an antidepressant often have their initial medication switched or combined with a second drug. Many clinicians weigh the possibility of adverse side effects when deciding between strategies. New research in the latest issue of General Hospital Psychiatry now suggests one strategy may not be any more likely to be harmful than the other.

Attention Deficit Hyperactivity Disorder (ADHD) medications do not increase the risk for heart disease or heart attack in children and young adults, according to a Vanderbilt study of 1.2 million patients taking drugs including Ritalin, Adderall, Concerta, and Strattera between 1998 and 2005. The study, published online today by the New England Journal of Medicine (NEJM) and authored by William Cooper, M.D., MPH, a Vanderbilt Professor of Pediatrics and Preventive Medicine, is the largest ever to examine potential risks posed by drugs to treat ADHD.

The poor safety profile of the smoking-cessation drug varenicline (Chantix™) makes it unsuitable for first-line use, according to a study published in the Nov. 2 edition of the journal PLoS One, an online publication of the Public Library of Science. Varenicline, which already carries a “black box warning” from the U.S. Food and Drug Administration (FDA), showed a substantially increased risk of reported depression or suicidal behavior compared to other smoking-cessation treatments.

A study by researchers at the University of Mississippi Medical Center (UMMC) and the University of California, San Francisco (UCSF) shows that rats given a popularly prescribed antidepressant during development exhibit brain abnormalities and behaviors characteristic of autism spectrum disorders. The findings suggest that taking a certain class of antidepressants known as selective serotonin reuptake inhibitors – SSRIs – during pregnancy might be one factor contributing to a dramatic rise in these developmental disorders in children.