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Different ingredients in marijuana appear to affect regions of the brain differently during brain processing functions involving responses to certain visual stimuli and tasks, according to a report in the January issue of Archives of General Psychiatry, one of the JAMA/Archives journals. Sagnik Bhattacharyya, M.B.B.S., M.D., Ph.D, at the Institute of Psychiatry, King’s College in London, and colleagues studied 15 healthy men, who were occasional marijuana users, to examine the effects of Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) on regional brain function during salience processing, which is how people perceive things around them.

Cigarette and alcohol use by eighth, 10th and 12th-graders are at their lowest point since the Monitoring the Future (MTF) survey began polling teenagers in 1975, according to this year’s survey results. However, this positive news is tempered by a slowing rate of decline in teen smoking as well as continued high rates of abuse of other tobacco products (e.g., hookahs, small cigars, smokeless tobacco), marijuana, and prescription drugs. The survey results, announced today during a news conference at the National Press Club, appear to show that more teens continue to abuse marijuana than cigarettes; and alcohol is still the drug of choice among all three age groups queried.

Nicotine replacement therapy and smoking cessation intervention programs are associated with positive outcomes among current smokers, according to two studies in the November 28 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. “Despite advances in clinical care and policy, rates of smoking cessation have held constant in the past decade, indicating a need for novel approaches,” the authors write as background information in one of the articles.

A survey of more than 33,000 Italian high school students reveals that both underweight and overweight teens consume 20 to 40% more illegal drugs than their normal-weight peers. The work, led by Sabrina Molinaro and Francesca Denoth of the Italian National Research Council, is reported in the Nov. 16 issue of the online journal PLoS ONE. Check the end of this report for a link to download the full-text article.

There is a greater risk that children of adult problem drinkers will consume more alcohol after stressful situations. This was revealed in research by Anna Söderpalm Gordh from the Sahlgrenska Academy at the University of Gothenburg, Sweden. It has long been known that alcoholics’ children are 50% more likely to have a drink problem in the future, and this new study sheds new light on this link.

In the first worldwide study of its kind, scientists from Toronto’s Centre for Addiction and Mental Health (CAMH) found evidence that heavy methamphetamine users might have a higher risk of developing schizophrenia. This finding was based on a large study comparing the risk among methamphetamine users not only to a group that did not use drugs, but also to heavy users of other drugs. Methamphetamine and other amphetamine-type stimulants are the second most common type of illicit drug used worldwide.

Substance use is widespread among adolescents in the United States, particularly among those of Native American, white, Hispanic and multiple race/ethnicity, and these groups are also disproportionally affected by substance-related disorders, according to a report in the November issue of Archives of General Psychiatry, one of the JAMA/Archives journals. The research was conducted by Li-Tzy Wu, Sc.D., of Duke University Medical Center, Durham, N.C., and colleagues.

Heavy alcohol consumption may be linked to a greater risk of developing lung cancer, while higher BMI and increased consumption of black tea and fruit are associated with lower risk of the deadly disease. In three separate studies presented at CHEST 2011, the 77th annual meeting of the American College of Chest Physicians (ACCP), heavy alcohol consumption was related to increased risk of lung cancer, while specific ethnic groups, including African American men and Asian women, had slightly higher risks for lung cancer.

Young people who are genetically vulnerable to depression should be extra careful about using cannabis: smoking cannabis leads to an increased risk of developing depressive symptoms. This has emerged from research carried out by Roy Otten at the Behavioural Science Institute of Radboud University Nijmegen that is published in the online version of the scientific journal Addiction Biology. Two-thirds of the population have the gene variant that makes one sensitive to depression.

Social media websites, such as Facebook and MySpace, may reveal information that could identify underage college students who may be at risk for problem drinking, according to a report published Online First by Archives of Pediatrics and Adolescent Medicine, one of the JAMA/Archives journals. The research was conducted by Megan A. Moreno, M.D., M.S.Ed., M.P.H., of the University of Wisconsin – Madison, and colleagues.